Article

Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic <i>Escherichia coli</i> in human urine

2025-10-31

Abstract excerpt

Urinary tract infections (UTIs) are among the most common infectious diseases, causing over 400 million cases and 260,000 deaths annually. Women are disproportionately affected, with ∼50% experiencing at least one UTI during their lifetime and 20–30% suffering from recurrent infections. Uropathogenic Escherichia coli (UPEC), which accounts for ∼75% of cases, employs diverse virulence factors to persist and evade...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dde3593d-65d5-5121-80e4-2e735cb9e083
DOI: 10.1101/2025.10.31.685768

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic <i>Escherichia coli</i> in human urineDOI 10.1101/2025.10.31.685768Read

Decoding <i>E. coli</i> ’s Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and StrainsSemantic proximity Read

Functional and genetic adaptations contributing to <i>Enterococcus faecalis</i> persistence in the female urinary tractSemantic proximity Read

Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective TreatmentSemantic proximity Read

Host-specific induction of <i>Escherichia coli</i> fitness genes during human urinary tract infectionSemantic proximity Read

The Small RNA MicC is a Multifunctional Regulator of Extraintestinal Pathogenic <i>Escherichia coli</i> Fitness across Multiple Host NichesSemantic proximity Read

Uropathogenic <i>Escherichia coli</i> wield enterobactin-derived catabolites as siderophoresSemantic proximity Read

Defining a Molecular Signature for Uropathogenic versus Urocolonizing Escherichia coli: The Status of the Field and New Clinical Opportunities.Semantic proximity Read

Mobile-CRISPRi: Enabling Genetic Analysis of Diverse BacteriaSemantic proximity Read

Disabling iron uptake and pilus assembly in uropathogenic Escherichia coli using CRISPR-Cas9: a step toward antivirulence therapySemantic proximity Read

Metabolomics survey of uropathogenic bacteria in human urineSemantic proximity Read

Phenotypic Assessment of Clinical <i>Escherichia coli</i> Isolates Predicts Uropathogenic PotentialSemantic proximity Read

Mapping Niche-specific Two-Component System Requirements in Uropathogenic <i>Escherichia coli</i>Semantic proximity Read