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The Gene Encoding Ornithine Decarboxylase for Putrescine Biosynthesis Is Essential for the Viability of <i>Fusobacterium nucleatum</i>

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Fusobacterium nucleatum is a Gram-negative anaerobe associated with periodontitis and colorectal cancer. It secretes putrescine, a polyamine that promotes biofilm formation by oral co-colonizers and enhances the proliferation of cancer cells. However, the physiological importance of putrescine for F. nucleatum itself remains unexplored. Here, we show that putrescine biosynthesis, mediated by th...

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Literature Corpus work
275e83ab-e03a-560f-aee9-df735a349ae8
DOI
10.1101/2025.09.02.673652
Open publication

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