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Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary

5 Jun 2025

Abstract excerpt

In 1998, Arlette Darfeuille-Michaud, Christel Neut and Jean-Frederic Colombel discovered a novel pathovar of Escherichia coli , adherent and invasive Escherichia coli (AIEC), in the ileum of patients with Crohn’s disease (CD), that was genetically distinct from diarrheagenic E. coli , could adhere to and invade intestinal epithelial cells and survive in macrophages. The consistent association between AIEC and CD...

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PMID: 40473402
DOI: 10.1136/gutjnl-2025-335331

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