Article

Oxalyl-CoA decarboxylase is a major and specific virulence factor for Adherent Invasive Escherichia coli

2026-01-12

Abstract excerpt

<title>Abstract</title> <p>Adherent-invasive Escherichia coli (AIEC) are enriched in the gut microbiota of patients with Crohn’s disease (CD), but bacterial genes underlying their role in intestinal inflammation remain poorly defined. By integrating in vivo whole-genome transposon sequencing (TnSeq) with and without colitis conditions, RNA sequencing and mechanistic experiments, we identified oxc, which encodes o...

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Literature Corpus work: 340fe590-1fcf-544e-82ac-9ec11f77fcb3
DOI: 10.21203/rs.3.rs-8320012/v1

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