Article

Genetic architecture of treatment-resistant schizophrenia across East Asian and European cohorts: insights from GWAS, TWAS, and synaptic pathway analyses

2026-08-10

Abstract excerpt

In about a quarter of people with schizophrenia-spectrum disorder (SSD), the illness is unresponsive to standard antipsychotic treatment, yet the biological mechanisms underlying this remain poorly understood. Although such treatment-resistant schizophrenia (TRS) shares a substantial genetic liability with treatment-responsive schizophrenia, the limited efficacy of dopamine antagonists in TRS indicates that mechan...

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Literature Corpus work: 81b0e275-32aa-57c1-a30d-c509ef299414
DOI: 10.64898/2026.08.06.26359853

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