Article
Enhancing genetic discovery through narrow phenotyping in schizophrenia.
Journal of psychiatric research - 1 Jan 2025
Yakovchik Anna, Mamchur Aleksandra, Kashtanova Daria, Ivanov Mikhail, Zelenova Elena, Bruttan Maria, Matkava Lorena, Terekhov Mikhail, Nekrasova Aleksandra, Nekrasov Aleksander, Mitrofanov Sergey, Astafieva Vasilisa, Shingaliev Andrey, Pavlov Konstantin, Pavlova Olga, Nebogina Kira, Morozova Anna, Kozlov Aleksander, Yudin Vladimir, Makarov Valentin, Keskinov Anton, Kraevoy Sergey, Yudin Sergey, Skvortsova Veronika
Abstract excerpt
BACKGROUND: Schizophrenia varies greatly from person to person, mainly because of its polygenic nature. Consequently, schizophrenia patients form distinct subphenotypes of schizophrenia, with specific symptom patterns and outcomes. METHODS: This study included 4257 adults, with long-term schizophrenia (control - 8955 individuals) who were assessed for schizophrenia with potentially severe outcomes based on...
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