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Article

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling.

Schizophrenia research - 1 Sept 2018

Schijven Dick, Kofink Daniel, Tragante Vinicius, Verkerke Marloes, Pulit Sara L, Kahn René S, Veldink Jan H, Vinkers Christiaan H, Boks Marco P, Luykx Jurjen J

Abstract excerpt

Large-scale genome-wide association studies (GWAS) have implicated many low-penetrance loci in schizophrenia. However, its pathological mechanisms are poorly understood, which in turn hampers the development of novel pharmacological treatments. Pathway and gene set analyses carry the potential to generate hypotheses about disease mechanisms and have provided biological context to genome-wide data of...

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PMID: 29653892
DOI: 10.1016/j.schres.2018.03.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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