Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.

Nature human behaviour - 1 Mar 2025

Dang Xinglun, Teng Zhaowei, Yang Yongfeng, Li Wenqiang, Liu Jiewei, Hui Li, Zhou Dongsheng, Gong Daohua, Dai Shan-Shan, Li Yifan, Li Xingxing, Lv Luxian, Zeng Yong, Yuan Yonggui, Ma Xiancang, Liu Zhongchun, Li Tao, Luo Xiong-Jian

Abstract excerpt

Genome-wide association studies (GWASs) have reported multiple risk loci for schizophrenia (SCZ). However, the majority of the associations were from populations of European ancestry. Here we conducted a large-scale GWAS in Eastern Asian populations (29,519 cases and 44,392 controls) and identified ten Eastern Asian-specific risk loci, two of which have not been previously reported. A further cross-ancestry GWAS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to East Asian People
Share to MAPT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Schizophrenia

Source

Identifiers

PMID: 39753749
DOI: 10.1038/s41562-024-02091-4

Genes

ACE
ABCB9
CA14
CNNM2
GATAD2A
MAPK3
MAPT
SNAP91

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.PMID 39753749Read ↗

Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia.Semantic proximity Read ↗

Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients.Semantic proximity Read ↗

A comprehensive family-based replication study of schizophrenia genes.Semantic proximity Read ↗

Genetic architecture of schizophrenia: a review of major advancements.Semantic proximity Read ↗

Biological Insights from Schizophrenia-associated Loci in Ancestral PopulationsSemantic proximity Read ↗

Comparative genetic architectures of schizophrenia in East Asian and European populations.Semantic proximity Read ↗

Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk.Semantic proximity Read ↗

SZGR 2.0: a one-stop shop of schizophrenia candidate genes.Semantic proximity Read ↗

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.Semantic proximity Read ↗

Unraveling Genetic Variants underlying Schizophrenia Phenotypes: An Original GWAS in Hong Kong Chinese with Cross-Ethnic Meta-Analysis and Predictive ModelingSemantic proximity Read ↗

Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective.Semantic proximity Read ↗

Genetic studies of schizophrenia: an update.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.