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Article

Systems-Level Analysis of Genetic Variants Reveals Functional and Spatiotemporal Context in Treatment-resistant Schizophrenia.

Molecular neurobiology - 1 May 2022

Talarico Fernanda, Costa Giovany Oliveira, Ota Vanessa Kiyomi, Santoro Marcos Leite, Noto Cristiano, Gadelha Ary, Bressan Rodrigo, Azevedo Hatylas, Belangero Sintia Iole

Abstract excerpt

Treatment-resistant schizophrenia (TRS) occurs in one-third of the patients, but the molecular determinants of poor antipsychotic response remain unclear. We compared genetic data of patients with TRS (n = 63) with non-TRS (n = 111) by polygenic risk scores (PRS) calculated by PRSice software using PGC2_SCZ (Psychiatric Genomics Consortium - Schizophrenia) data. TRS criteria followed the International...

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PMID: 35278208
DOI: 10.1007/s12035-022-02794-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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