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Article

Mutant prion protein acquires resistance to protease in mouse neuroblastoma cells.

The Journal of general virology - 1 May 2002

Wegner C, Römer A, Schmalzbauer R, Lorenz H, Windl O, Kretzschmar H A

Abstract excerpt

Conversion of the cellular isoform of the prion protein (PrP(C)) into the pathogenic isoform (PrP(Sc)) is thought to be the causative event in prion diseases. Biochemically, PrP(Sc) differs from PrP(C) in its partial resistance to proteinase K (PK). The amino acid sequence AGAAAAGA, comprising residues 112-119 of the murine PrP(C), has been shown to be amyloidogenic and evolutionarily conserved. To assess the...

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PMID: 11961279
DOI: 10.1099/0022-1317-83-5-1237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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