Article
Recombinant human growth hormone and insulin-like growth factor I induce PrP gene expression in PC12 cells.
Biochemical and biophysical research communications - 15 Nov 1993
Lasmézas C, Deslys J P, Dormont D
Abstract excerpt
Growth factors like NGF are known to increase the expression of PrP gene, a housekeeping gene which is responsible for susceptibility to transmissible spongiform encephalopathies. We evaluated in vitro the effect of recombinant human growth hormone (hGH) and one of its in vivo effectors, the insu...
Topics
- Animals
- Blotting, Northern
- Brain
- Gene Expression
- Genetic Predisposition to Disease
- Growth Hormone
- Humans
- Insulin-Like Growth Factor I
- Mice
- Nerve Growth Factors
- Neurons
- PC12 Cells
- PrPSc Proteins
- Prion Diseases
- Prions
- RNA, Messenger
- Recombinant Proteins