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Article

Cooperative binding of dominant-negative prion protein to kringle domains.

Journal of molecular biology - 30 May 2003

Ryou Chongsuk, Prusiner Stanley B, Legname Giuseppe

Abstract excerpt

Conversion of the cellular prion protein (PrP(C)) to the pathogenic isoform (PrP(Sc)) is a major biochemical alteration in the progression of prion disease. This conversion process is thought to require interaction between PrP(C) and an as yet unidentified auxiliary factor, provisionally designated protein X. In searching for protein X, we screened a phage display cDNA expression library constructed from...

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Identifiers

PMID: 12758079
DOI: 10.1016/s0022-2836(03)00342-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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