Article
Stress-protective signalling of prion protein is corrupted by scrapie prions.
The EMBO journal - 23 Jul 2008
Rambold Angelika S, Müller Veronika, Ron Uri, Ben-Tal Nir, Winklhofer Konstanze F, Tatzelt Jörg
Abstract excerpt
Studies in transgenic mice revealed that neurodegeneration induced by scrapie prion (PrP(Sc)) propagation is dependent on neuronal expression of the cellular prion protein PrP(C). On the other hand, there is evidence that PrP(C) itself has a stress-protective activity. Here, we show that the toxic activity of PrP(Sc) and the protective activity of PrP(C) are interconnected. With a novel co-cultivation assay, we...
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