Article
Engineering the prion protein using chemical synthesis.
The journal of peptide research : official journal of the American Peptide Society - 1 Nov 2001
Ball H L, King D S, Cohen F E, Prusiner S B, Baldwin M A
Abstract excerpt
In recent years, the technology of solid-phase peptide synthesis (SPPS) has improved to the extent that chemical synthesis of small proteins may be a viable complementary strategy to recombinant expression. We have prepared several modified and wild-type prion protein (PrP) polypeptides, of up to 112 residues, that demonstrate the flexibility of a chemical approach to protein synthesis. The principal event in...
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