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Article

Proteolytic fragmentation of the murine prion protein: role of Tyr-128 and His-177.

FEBS letters - 17 Dec 1999

Perera W S, Hooper N M

Abstract excerpt

The prion protein (PrP) has been proposed to display sequence and structural similarities to membrane-anchored signal peptidases [Glockshuber et al. (1998) FEBS Lett. 426, 291-296]. We have investigated the role of Tyr-128 and His-177 in the proteolytic fragmentation of murine PrP by mutating these residues to Phe and Leu, respectively, and expressing the resultant mutants in the human neuroblastoma SH-SY5Y. Both...

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Identifiers

PMID: 10606736
DOI: 10.1016/s0014-5793(99)01648-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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