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Article

Physiological Role of the Cellular Prion Protein (PrP<sup>c</sup>): Protein Profiling Study in Two Cell Culture Systems

7 Jun 2008

Abstract excerpt

The physiological role of the cellular prion protein (PrP (c)) is still not fully understood. Current evidence strongly suggests that PrP (c) overexpression in different cell lines sensitizes cells to apoptotic stimuli through a p53 dependent pathway. On the other hand, an expression of PrP (c) in PrP (c)-deficient cells undergoing apoptosis exhibited repeatedly antiapoptotic effects. Therefore, the...

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PMID: 18537284
DOI: 10.1021/pr7007187

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