Article

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancer

2020-06-06

Abstract excerpt

Targeting cancer stem cells (CSCs) can serve as an effective approach toward limiting resistance to therapies and the development of metastases in many forms of cancer. While basal breast cancers encompass cells with CSC features, rational therapies remain poorly established. Here, we show that receptor tyrosine kinase Met signalling promotes the activity of the Hippo component YAP in basal breast cancer. Further...

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Identifiers and source

Literature Corpus work: 81a57944-8ccb-5271-85d5-2038f0c5a171
DOI: 10.1101/2020.06.05.115881

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