Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.

EMBO reports - 1 Feb 2016

Di Agostino Silvia, Sorrentino Giovanni, Ingallina Eleonora, Valenti Fabio, Ferraiuolo Maria, Bicciato Silvio, Piazza Silvano, Strano Sabrina, Del Sal Giannino, Blandino Giovanni

Abstract excerpt

Mutant p53 proteins are present in more than half of human cancers. Yes-associated protein (YAP) is a key transcriptional regulator controlling organ growth, tissue homeostasis, and cancer. Here, we report that these two determinants of human malignancy share common transcriptional signatures. YAP physically interacts with mutant p53 proteins in breast cancer cells and potentiates their pro-proliferative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC2 Protein Kinase
Share to Cyclin A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin B

Share to Cyclin-Dependent Kinases

Share to HCT116 Cells

Share to MCF-7 Cells

Share to Phosphoproteins

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26691213
DOI: 10.15252/embr.201540488
PMCID: PMC5290815

Genes

CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.PMID 26691213Read ↗

Yes-Associated Protein (YAP) Modulates Oncogenic Features and Radiation Sensitivity in Endometrial CancerSemantic proximity Read ↗

Yap suppresses T-cell function and infiltration in the tumor microenvironmentSemantic proximity Read ↗

The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.Semantic proximity Read ↗

NELFA-mediated promoter-proximal pausing restrains YAP-driven transcription and shapes context-dependent outcomes in breast cancerSemantic proximity Read ↗

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the <i>Drosophila Hippo</i> PathwaySemantic proximity Read ↗

Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53Semantic proximity Read ↗

Yap suppresses T cell function and infiltration in the tumor microenvironmentSemantic proximity Read ↗

Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human CancersSemantic proximity Read ↗

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.Semantic proximity Read ↗

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancerSemantic proximity Read ↗

Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancer.Semantic proximity Read ↗

Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.