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Article

YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer Susceptibility.

Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2026

Fresques Tara, Lopez Jennifer C, Hussey Deborah, Miyano Masaru, Garbe James C, Hinz Stefan, Sayaman Rosalyn W, Li Aimin, Schmolze Daniel, Van Bedford Serenity, Stampfer Martha R, LaBarge Mark A

Abstract excerpt

YAP1 is a cotranscription factor that promotes malignant and stem cell properties in cancer. We previously found that YAP1 dysregulation is associated with aging in human mammary epithelia. With increased age, YAP1 expression changes in luminal epithelial cells, the prospective breast cancer cell of origin. Because age is a significant risk factor for breast cancer, we tested whether YAP1 dysregulation acted...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Gene Expression Regulation, Neoplastic

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Share to Phosphoproteins

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Source

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Identifiers

PMID: 41431390
DOI: 10.1158/1940-6207.CAPR-25-0027
PMCID: PMC13040214

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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