Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subclonal β-catenin/YAP signaling heterogeneity accelerates ovarian cancer metastasis through a senescence-associated secretory phenotype.

Cell death & disease - 23 Apr 2026

To Sally K Y, Yang Yibin, Shi Zeyu, Fung Katie S W, Lai Sook Ling, Li Joshua J X, Ip Philip P C, Wong Alice S T

Abstract excerpt

Intratumoral heterogeneity in metastatic cancers complicates effective treatment, as distinct tumor subclones display varying drug sensitivities and metastatic capabilities, interacting through mechanisms that remain poorly understood. In this study, we utilized an isogenic ovarian cancer cell pair distinguished by differential β-catenin signaling: non-metastatic (NM) cells with low β-catenin and highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cellular Senescence

Share to Neoplasm Metastasis

Share to Ovarian Neoplasms

Share to Transcription Factors

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42026023
DOI: 10.1038/s41419-026-08737-7
PMCID: PMC13237159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subclonal β-catenin/YAP signaling heterogeneity accelerates ovarian cancer metastasis through a senescence-associated secretory phenotype.PMID 42026023Read ↗

A Selective β−Catenin‐Metadherin/CEACAM1‐CCL3 Axis Mediates Metastatic Heterogeneity upon Tumor–Macrophage InteractionSemantic proximity Read ↗

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancerSemantic proximity Read ↗

Tumorigenicity of Ascites-Derived Tumor Cells: Insights Into the Molecular Mechanisms of Ovarian Cancer Progression and Therapy ResistanceSemantic proximity Read ↗

The variant senescence-associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia-inducible factor-1α.Semantic proximity Read ↗

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotypeSemantic proximity Read ↗

The senescent mesothelial matrix accentuates colonization by ovarian cancer cellsSemantic proximity Read ↗

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases.Semantic proximity Read ↗

The senescent mesothelial matrix accentuates colonization by ovarian cancer cellsSemantic proximity Read ↗

Carcinoma associated mesenchymal stem cells promote ovarian cancer metastasis by increasing tumor heterogeneity through direct mitochondrial transferSemantic proximity Read ↗

The senescence-associated secretory phenotype in ovarian cancer dissemination.Semantic proximity Read ↗

YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer Susceptibility.Semantic proximity Read ↗

Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.