Article

The basement membrane regulates the cellular localization and the cytoplasmic interactome of Yes-Associated Protein (YAP) in mammary epithelial cells

2023-08-24

Abstract excerpt

The Hippo pathway, a signaling cascade involved in the regulation of organ size and several other processes, acts as a conduit between ECM cues and cellular responses. We asked whether the basement membrane (BM), a specialized ECM component known to induce quiescence and differentiation in mammary epithelial cells, would regulate the localization, activity and interactome of YAP, a Hippo pathway effector. To addre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ac26efa-dd48-5dfc-9bb8-7fb028d1a9ee
DOI: 10.1101/2023.08.23.554465

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The basement membrane regulates the cellular localization and the cytoplasmic interactome of Yes-Associated Protein (YAP) in mammary epithelial cellsDOI 10.1101/2023.08.23.554465Read

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read

Hippo Pathway Dysregulation in Thymic Epithelial Tumors (TETs): Associations with Clinicopathological Features and Patients’ PrognosisSemantic proximity Read

Implications for precision medicine and the reciprocal control of microRNAs by Hippo and TAZ signaling in breast cancerSemantic proximity Read

Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway.Semantic proximity Read

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.Semantic proximity Read

YAP and β-catenin co-operate to drive oncogenesis in basal breast cancerSemantic proximity Read

Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancerSemantic proximity Read

YAP/TAZ upstream signals and downstream responses.Semantic proximity Read

YAP activates the Hippo pathway in a negative feedback loop.Semantic proximity Read

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187Semantic proximity Read

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of Tuberous Sclerosis ComplexSemantic proximity Read

Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imagingSemantic proximity Read