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Article

Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor

6 Aug 2018

Abstract excerpt

Abstract Breast cancer remains the most common malignant disease in women worldwide. Despite advances in detection and therapies, studies are still needed to understand the mechanisms underlying this cancer. Cancer stem cells (CSC) play an important role in tumor formation, growth, drug resistance, and recurrence. Here, it is demonstrated that the transcription factor RUNX1, well known as essential for...

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PMID: 30082484
DOI: 10.1158/1541-7786.mcr-18-0135

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