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The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells

20 Apr 2023

Abstract excerpt

BACKGROUND: Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. METHODS: Four triple negative breast cancer cell lines derived from CSC of two patient-derived xenografts (PDXs), AS-B145, AS-B145-1R, AS-B244, and AS-B244-1R, were used to elucidate the role of YAP in BCSCs. YAP silenced BCSCs were analyzed by cell proliferation,...

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PMID: 37081542
DOI: 10.1186/s12964-023-01088-2

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