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Article

Phenotypic analysis of catastrophic childhood epilepsy genes.

Communications biology - 3 Jun 2021

Griffin Aliesha, Carpenter Colleen, Liu Jing, Paterno Rosalia, Grone Brian, Hamling Kyla, Moog Maia, Dinday Matthew T, Figueroa Francisco, Anvar Mana, Ononuju Chinwendu, Qu Tony, Baraban Scott C

Abstract excerpt

Genetic engineering techniques have contributed to the now widespread use of zebrafish to investigate gene function, but zebrafish-based human disease studies, and particularly for neurological disorders, are limited. Here we used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing catastrophic childhood epilepsies. We evaluated larval phenotypes using electrophysiological, behavioral,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34083748
DOI: 10.1038/s42003-021-02221-y
PMCID: PMC8175701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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