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Knockdown of <i>NeuroD2</i> leads to seizure-like behaviour, brain neuronal hyperactivity and a leaky blood-brain barrier in a <i>Xenopus laevis</i> tadpole model of DEE75

2023-12-08

Abstract excerpt

Developmental and Epileptic Encephalopathies (DEE) are a genetically diverse group of severe, early onset seizure disorders. DEE are normally identified clinically in the first six months of life by the presence of frequent, difficult to control seizures and accompanying stalling or regression of development. DEE75 results from de novo mutations of the NEUROD2 gene that result in loss of activity of the encoded...

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Literature Corpus work
4f2e768e-9601-5cef-a3a0-33d3b4ac6232
DOI
10.1101/2023.12.06.570491
Open publication

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Knockdown of <i>NeuroD2</i> leads to seizure-like behaviour, brain neuronal hyperactivity and a leaky blood-brain barrier in a <i>Xenopus laevis</i> tadpole model of DEE75DOI 10.1101/2023.12.06.570491
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