Article

Orphan cytochrome P450 20A1 CRISPR/Cas 9 mutants and neurobehavioral phenotypes in zebrafish

2021-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Orphan cytochrome P450 (CYP) enzymes are those for which biological substrates and function(s) are unknown. Cytochrome P450 20A1 (CYP20A1) is the last human orphan P450 enzyme, and orthologs occur as single genes in every vertebrate genome sequenced to date. The occurrence of high levels of CYP20A1 transcripts in human substantia nigra and hippocampus and abundant maternal transcripts in zebraf...

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Literature Corpus work: 9714b4a9-34fc-5f2b-8286-583971ab4d58
DOI: 10.1101/2021.07.23.453406

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