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Article

Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Oct 2010

Hortopan Gabriela A, Dinday Matthew T, Baraban Scott C

Abstract excerpt

Disruption of E3 ubiquitin ligase activity in immature zebrafish mind bomb mutants leads to a failure in Notch signaling, excessive numbers of neurons, and depletion of neural progenitor cells. This neurogenic phenotype is associated with defects in neural patterning and brain development. Because developmental brain abnormalities are recognized as an important feature of childhood neurological disorders such as...

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Identifiers

PMID: 20943912
DOI: 10.1523/JNEUROSCI.1887-10.2010
PMCID: PMC2962868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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