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Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis

1 Apr 2022

Abstract excerpt

Bioinformatic analysis of 94 patient-derived xenografts (PDXs), cell lines, and organoids (PCOs) identifies three intrinsic transcriptional subtypes of metastatic castration-resistant prostate cancer: androgen receptor (AR) pathway + prostate cancer (PC) (ARPC), mesenchymal and stem-like PC (MSPC), and neuroendocrine PC (NEPC). A sizable proportion of castration-resistant and metastatic stage PC (M-CRPC) cases...

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PMID: 35385726
DOI: 10.1016/j.celrep.2022.110595

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