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Article

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

11 Oct 2024

Abstract excerpt

Abstract Lineage plasticity is a hallmark of cancer progression that impacts therapy outcomes, yet the mechanisms mediating this process remain unclear. Here, we introduce a versatile in vivo platform to interrogate neuroendocrine lineage transformation throughout prostate cancer progression. Transplanted mouse prostate organoids with human-relevant driver mutations ( Rb1 − / − ; Trp53 − / − ; cMyc + or Pten − /...

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PMID: 39394434
DOI: 10.1038/s43018-024-00838-6

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