Article

Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival

2025-04-30

Abstract excerpt

<h4>Background</h4> Cancer progression is often accompanied by dedifferentiation and acquisition of stem cell-like properties (stemness). In prostate cancer (PCa), lineage plasticity and therapy resistance remain major clinical challenges, yet a unified quantitative transcriptomic framework connecting stemness, androgen receptor (AR) signaling, castration resistance, and disease progression across the PCa continu...

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Literature Corpus work: 65b4b484-1f64-51e7-8f4c-f8787a8679cc
DOI: 10.1101/2025.04.27.650697

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