Article

The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer

2022-03-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> To resist lineage-dependent therapies such as androgen receptor inhibition in prostate cancer, cancer cells often adopt a stem-like state resulting in lineage-plasticity and phenotypic heterogeneity. We assessed the dynamics of lineage determination and cellular subpopulation expansion in treatment-resistant adenocarcinoma, amphicrine, and small cell neuroendocrine castrate res...

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Literature Corpus work: a8f580f4-0feb-556d-8b16-fe240fffba52
DOI: 10.1101/2022.03.24.484651

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