Article

The polygenic risk score and inter-familial heterogeneity in multigenerational families affected by schizophrenia and bipolar disorder

2026-08-07

Abstract excerpt

<title>Abstract</title> <p>In the past two decades, the focus on genome-wide association studies in large samples of unrelated patients has overshadowed family genetic studies. Therefore, little is still known about the levels and effects of the transmission of polygenic risk scores (PRS) among familial cases of schizophrenia (SZ) or bipolar disorder (BD) and their unaffected relatives. Prior research has shown t...

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Literature Corpus work: 8187593f-ea12-5ca8-a768-20b16683af23
DOI: 10.21203/rs.3.rs-10091685/v1

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