Article

The polygenic risk score and inter-familial heterogeneity in multigenerational families affected by schizophrenia and bipolar disorder

2026-06-08

Abstract excerpt

In the past two decades, the focus on genome-wide association studies in large samples of unrelated patients has overshadowed family genetic studies. Therefore, little is still known about the levels and effects of the transmission of polygenic risk scores (PRS) among familial cases of schizophrenia (SZ) or bipolar disorder (BD) and their unaffected relatives. Prior research has shown that PRS are elevated in both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6254c964-5ffb-5e27-9e8e-85601d0bf2c9
DOI: 10.64898/2026.06.08.26354912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The polygenic risk score and inter-familial heterogeneity in multigenerational families affected by schizophrenia and bipolar disorderDOI 10.64898/2026.06.08.26354912Read

The polygenic risk score and inter-familial heterogeneity in multigenerational families affected by schizophrenia and bipolar disorderSemantic proximity Read

Polygenic risk scores distinguish patients from non-affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi-affected kindreds.Semantic proximity Read

Polygenic risk scores in psychiatry: Will they be useful for clinicians?Semantic proximity Read

Applying polygenic risk scoring for psychiatric disorders to a large family with Bipolar Disorder and Major Depressive DisorderSemantic proximity Read

Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals.Semantic proximity Read

Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.Semantic proximity Read

Polygenic risk scores across the extended psychosis spectrum.Semantic proximity Read

Genetic risk modeling approaches to resolve phenotypic and molecular heterogeneity in psychiatric disorders.Semantic proximity Read

Polygenic risk score and the psychosis continuum model.Semantic proximity Read

Research review: Polygenic methods and their application to psychiatric traits.Semantic proximity Read

The role of bipolar polygenic risk score in the familial transmission of bipolar disorder-An updated analysis.Semantic proximity Read

Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric DisordersSemantic proximity Read