Article

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care System

2022-02-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Serious mental illnesses, including schizophrenia, bipolar disorder and depression are heritable, highly multifactorial disorders and major causes of disability worldwide. Polygenic risk scores (PRS) aggregate variants identified from genome-wide association studies (GWAS) into individual-level estimates of liability, and are a promising tool for clinical risk stratification....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6b08b46a-0ed3-5321-b6d0-9dd95c00c67b
DOI: 10.1101/2022.02.16.22271088

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care SystemDOI 10.1101/2022.02.16.22271088Read

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care SystemSemantic proximity Read

Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systemsSemantic proximity Read

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record dataSemantic proximity Read

Genetic risk modeling approaches to resolve phenotypic and molecular heterogeneity in psychiatric disorders.Semantic proximity Read

Association Between Psychiatric Polygenic Scores, Healthcare Utilization and Comorbidity BurdenSemantic proximity Read

Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals.Semantic proximity Read

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traitsSemantic proximity Read

Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.Semantic proximity Read

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits.Semantic proximity Read

Impact of Selection Bias on Polygenic Risk Score Estimates in Healthcare SettingsSemantic proximity Read

Impact of selection bias on polygenic risk score estimates in healthcare settings.Semantic proximity Read

Polygenic risk scores lack prognostic value for adults with severe mental illnessSemantic proximity Read