Article
Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2015
Fullerton Janice M, Koller Daniel L, Edenberg Howard J, Foroud Tatiana, Liu Hai, Glowinski Anne L, McInnis Melvin G, Wilcox Holly C, Frankland Andrew, Roberts Gloria, Schofield Peter R, Mitchell Philip B, Nurnberger John I
Abstract excerpt
Recent studies have revealed the polygenic nature of bipolar disorder (BP), and identified common risk variants associated with illness. However, the role of common polygenic risk in multiplex families has not previously been examined. The present study examined 249 European-ancestry families from the NIMH Genetics Initiative sample, comparing subjects with narrowly defined BP (excluding bipolar II and recurrent...
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