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Drosophila Bchs overexpression recapitulates human WDFY3 neurodevelopmental phenotypes with implications for glial cell involvement in altered head circumference

2023-10-17

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The autophagy adaptor WDFY3 is linked to neurodevelopmental delay and altered brain size. Loss-of-function variants are associated with an increased brain size in both humans and mice. We thus, hypothesized that the microcephaly observed in some of the patients may be related to a gain-of-function of the WDFY3 gene product. While the role of WDFY3 loss-of-function has been studied extensively in neurons, little...

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Literature Corpus work: cb945d76-9b39-54fc-9e67-579568bc4b04
DOI: 10.1101/2023.10.16.562295

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Drosophila Bchs overexpression recapitulates human WDFY3 neurodevelopmental phenotypes with implications for glial cell involvement in altered head circumferenceDOI 10.1101/2023.10.16.562295Read

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<i>Drosophila Bchs</i> overexpression recapitulates human <i>WDFY3</i> neurodevelopmental phenotypes with implications for glial cell involvement in altered head circumference

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