Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A progenitor cell origin of myeloid malignancies.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2009

Haeno Hiroshi, Levine Ross L, Gilliland D Gary, Michor Franziska

Abstract excerpt

All cancers rely on cells that have properties of long-term self-renewal or "stemness" to maintain and propagate the tumor, but the cell of origin of most cancers is still unknown. Here, we design a stochastic mathematical model of hematopoietic stem and progenitor cells to study the evolutionary dynamics of cancer initiation. We consider different evolutionary pathways leading to cancer-initiating cells in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Lineage
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Models, Genetic

Share to Myeloid Progenitor Cells

Share to Myeloproliferative Disorders

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 19805346
DOI: 10.1073/pnas.0908107106
PMCID: PMC2757818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A progenitor cell origin of myeloid malignancies.PMID 19805346Read ↗

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.Semantic proximity Read ↗

Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in <i>JAK2</i> -mutant myeloproliferative neoplasmsSemantic proximity Read ↗

Inferring the initiation and development of myeloproliferative neoplasms.Semantic proximity Read ↗

Mathematical models of cancer stem cells.Semantic proximity Read ↗

Stochastic Dynamics of Hematopoietic Tumor Stem CellsSemantic proximity Read ↗

Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis.Semantic proximity Read ↗

A mathematical model of cancer stem cell driven tumor initiation: implications of niche size and loss of homeostatic regulatory mechanisms.Semantic proximity Read ↗

Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny.Semantic proximity Read ↗

The therapeutic implications of plasticity of the cancer stem cell phenotype.Semantic proximity Read ↗

Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasmsSemantic proximity Read ↗

Mathematical model for the cancer stem cell hypothesis.Semantic proximity Read ↗

Stochastic dynamics of cancer initiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.