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Article

Cell competition between wild-type and JAK2V617F mutant cells in a murine model of a myeloproliferative neoplasm

2020-08-27

Abstract excerpt

The myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by overproduction of mature blood cells and increased risk of transformation to frank leukemia. The acquired kinase mutation JAK2V617F plays a central role in a majority of these disorders. The hematopoietic stem cell (HSC) compartment in MPN is heterogeneous with the presence of both JAK2 wild-type and JAK2V617F mutant cells in m...

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Literature Corpus work
43ad57bd-4972-5d0c-87eb-50abfe20b213
DOI
10.1101/2020.08.26.267070
Open publication

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Cell competition between wild-type and JAK2V617F mutant cells in a murine model of a myeloproliferative neoplasmDOI 10.1101/2020.08.26.267070
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