Article

Logical modelling of myelofibrotic microenvironment predicts dysregulated progenitor stem cell crosstalk

2022-12-14

Abstract excerpt

Primary myelofibrosis is an untreatable age-related disorder of haematopoiesis in which a break in the crosstalk between progenitor Haematopoietic Stem Cells (HSCs) and neighbouring mesenchymal stem cells causes HSCs to rapidly proliferate and migrate out of the bone marrow. 90% of patients harbour mutations in driver genes that all converge to overactivate hematopoietic JAK-STAT signalling, which is thought to be...

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Literature Corpus work: d8ead2e7-5349-5b64-a1f2-f2f9b6765c97
DOI: 10.1101/2022.12.12.520119

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