Article
Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization.
Molecular pharmacology - 1 Dec 2012
Li Guo, Zhou Qi, Yu Yena, Chen Linjie, Shi Ying, Luo Jiansong, Benovic Jeffrey, Lu Jianxin, Zhou Naiming
Abstract excerpt
The human hydroxycarboxylic acid receptor 2 (HCA₂), also known as GPR109A and HM74a, was first identified as a niacin receptor and has recently received significant attention because of its potential to clinically modify plasma lipids in a favorable manner. Our recent studies have demonstrated that the niacin-induced internalization of HCA₂ receptors is regulated by G protein-coupled receptor kinase (GRK) 2 and...
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