Article
Transient downregulation of NR4A1 leads to impaired osteoblast differentiation through the TGF-ß pathway, and Elesclomol (STA-4783) rescues this phenotype.
Cell biochemistry and function - 1 Jul 2023
Muthurangan Manikandan, Elsafadi Mona, Siyal Abdulaziz, Kaimkhani Zahid Ali, Umrani Arbila, AlMuraikhi Nihal A, Alfayez Musaad, Abdelhady Essam Eldin, Alqahtani Hamad, Basavarajappa Santhosh, Aboul-Soud Mourad A M, Mahmood Amer
Abstract excerpt
Bone formation is regulated by numerous factors, such as transcription factors, cytokines, and extracellular matrix molecules. Human hormone nuclear receptors (hHNR) are a family of ligand-regulated transcription factors that are activated by steroid hormones, such as estrogen and progesterone, and various lipid-soluble signals, including retinoic acid, oxysterols, and thyroid hormone. We found that an hHNR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.