Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucocorticoids induce osteoporosis mediated by glucocorticoid receptor-dependent and -independent pathways.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2020

Jiang Yu, Lu Yajun, Jiang Xu, Hu Jiawei, Li Rong, Liu Yun, Zhu Guoxing, Rong Xiaoxu

Abstract excerpt

Clinically, glucocorticoids (GCs) are widely used to treat inflammation-related diseases; however, their long-term use causes side effects, such as osteoporosis and predisposition to bone fractures, known as glucocorticoid-induced osteoporosis (GIOP). Nr3c1 is the major glucocorticoid receptor, and its downstream signaling pathway is involved in regulating various intracellular physiological processes, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Glucocorticoids

Share to Osteoblasts

Share to Osteoporosis

Share to Receptors, Glucocorticoid

Share to Zebrafish

Source

Identifiers

PMID: 32044718
DOI: 10.1016/j.biopha.2020.109979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoids induce osteoporosis mediated by glucocorticoid receptor-dependent and -independent pathways.PMID 32044718Read ↗

Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene TranscriptionSemantic proximity Read ↗

Possible mechanisms of prednisolone-induced osteoporosis in zebrafish larva.Semantic proximity Read ↗

Zebrafish models for glucocorticoid-induced osteoporosisSemantic proximity Read ↗

Minireview: Live and Let Die: Molecular Effects of Glucocorticoids on Bone CellsSemantic proximity Read ↗

Prednisolone induces osteoporosis-like phenotypes via focal adhesion signaling pathway in zebrafish larvaeSemantic proximity Read ↗

Functions of Epimedin C in a zebrafish model of glucocorticoid‐induced osteoporosisSemantic proximity Read ↗

Glucocorticoid Receptor Regulates TNFSF11 Transcription by Binding to Glucocorticoid Responsive Element in TNFSF11 Proximal Promoter Region.Semantic proximity Read ↗

A Novel Patient-Derived Mutation in Glucocorticoid Receptor Reveals an Essential Role for DNA binding in Development and Endocrine RegulationSemantic proximity Read ↗

Molecular mechanisms of glucocorticoid resistance.Semantic proximity Read ↗

The miR-98-3p/JAG1/Notch1 axis mediates the multigenerational inheritance of osteopenia caused by maternal dexamethasone exposure in female rat offspringSemantic proximity Read ↗

MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3Semantic proximity Read ↗

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid ReceptorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.