Article
Mechanism of the regulation of organic cation/carnitine transporter 1 (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2007
Maeda Tomoji, Hirayama Masamichi, Kobayashi Daisuke, Miyazawa Keiji, Tamai Ikumi
Abstract excerpt
Recently, it was reported that the organic cation/carnitine transporter 1 (OCTN1, SLC22A4) is associated with chronic inflammatory diseases, such as rheumatoid arthritis (RA) and Crohn's disease. OCTN1 in humans is expressed in synovial tissues of individuals with rheumatoid arthritis. Furthermore octn1 in mice is expressed in inflamed joints with collagen-induced arthritis, a model of human arthritis, but not in...
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