Article

Pharmacological intervention of the FGF-PTH axis as a potential therapeutic for craniofacial ciliopathies

2022-04-22

Abstract excerpt

Ciliopathies represent a disease class characterized by a broad range of phenotypes including polycystic kidneys and skeletal anomalies. Ciliopathic skeletal phenotypes are among the most common and most difficult to treat due to a poor understanding of the pathological mechanisms leading to disease. Using an avian model ( talpid 2 ) for a human ciliopathy with skeletal anomalies (Orofaciodigital syndrome 14), w...

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Literature Corpus work: a5ba5451-42c6-5b61-bca7-6f7c3e2af0a4
DOI: 10.1101/2022.04.21.489105

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