Article

<i>ATRAID</i> regulates the action of nitrogen-containing bisphosphonates on bone

2018-06-04

Abstract excerpt

Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, are the most widely prescribed medications for diseases involving bone, with nearly 200 million prescriptions written annually. Recently, widespread use of N-BPs has been challenged due to the risk of rare but traumatic side effects such as atypical femoral fracture (AFFs) and osteonecrosis of the jaw (ONJ). N-BPs bind to and inhibit farnesyl diphos...

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Literature Corpus work: 7f13c18d-499a-5d7e-ae8a-370058d6aa52
DOI: 10.1101/338350

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