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Oxidative Stress-Induced Microglial CD22 Upregulation Impairs Phagocytosis and Exacerbates Huntington’s Disease

2026-03-13

Abstract excerpt

<h4>Background</h4> Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal polyglutamine expansion in mutant huntingtin (mHTT) and is characterized by movement dysfunction and neuronal loss. Siglecs, a family of sialic acid-binding proteins, are expressed on brain microglia and implicated in Alzheimer’s disease. Sialic acids are abundant in mammalian brains and cap the termini of the glyc...

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Literature Corpus work
81410baa-705a-5552-83be-ddf2513151b4
DOI
10.64898/2026.03.11.710967
Open publication

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Oxidative Stress-Induced Microglial CD22 Upregulation Impairs Phagocytosis and Exacerbates Huntington’s DiseaseDOI 10.64898/2026.03.11.710967
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