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A Two-Track Model of Striatal Degeneration in Huntington’s Disease: Independent Contributions of Cytoskeletal Damage and Immune Dysregulation Consistent with an Immune-Exhaustion-Like Profile

2026-01-23

Abstract excerpt

Huntington’s disease (HD) is characterized by progressive striatal atrophy and complex proteomic changes in the central nervous system. Using the ultrasensitive NULISA proteomic platform, we analyzed cerebrospinal fluid (CSF) from 88 persons with HD to dissect the biological correlates of gray matter loss. We identified a two-signal pattern of pathology. The first track, marked by the axonal damage protein Neurofi...

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Literature Corpus work
b6b58c31-3c24-5d5a-b31a-a28570a28405
DOI
10.20944/preprints202601.1806.v1
Open publication

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A Two-Track Model of Striatal Degeneration in Huntington’s Disease: Independent Contributions of Cytoskeletal Damage and Immune Dysregulation Consistent with an Immune-Exhaustion-Like ProfileDOI 10.20944/preprints202601.1806.v1
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