Article

Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation

2024-11-14

Abstract excerpt

Disrupted lipid homeostasis and neuroinflammation often co-exist in neurodegenerative disorders including Alzheimer’s disease (AD). However, the intrinsic connection and causal relationship between these deficits remain elusive. Our previous studies show that the loss of sulfatide (ST), a class of myelin-enriched lipids, causes AD-like neuroinflammatory responses, cognitive impairment, bladder enlargement, as well...

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Literature Corpus work: 78de5b39-a125-5750-9aa7-0a880761f121
DOI: 10.1101/2024.11.14.623651

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