Article

Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks

2020-05-02

Abstract excerpt

Mutations in the LRRK2 gene have been widely linked to Parkinson’s disease. The G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been extensively studied, yet the wide variety of cellular and network events directly or indirectly related to these mutations remain poorly understood. In this study, we structured multi-nodal human ne...

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Literature Corpus work: 812f6330-e959-530b-b5e9-83865d18c45d
DOI: 10.1101/2020.05.02.073726

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