Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.

Abstract excerpt

Reciprocal structure-function relationships underlie both healthy and pathological behaviours in complex neural networks. Thus, understanding neuropathology and network dysfunction requires a thorough investigation of the complex interactions between structural and functional network reconfigurations in response to perturbation. Such adaptations are often difficult to study in vivo. For example, subtle, evolving...

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